Based on the supplied Lymph Node Simulation Biological Manual v1.0. This independent project does not modify the Gut simulator.
Implemented: a 100- or 300-cell starting monolayer, native-antigen transport and finite capture, processing and pMHC-II loading, cognate CD4 priming, linked helper contacts, timed GC founding, finite divisions, a toy affinity mutation kernel, memory / plasma differentiation, secretion, failed-selection death and macrophage clearance.
Proposed assumptions: enriched cognate repertoires; pre-opsonized protein plus adjuvant; fixed positioning fields; all geometry, time and rate parameters. Two qualified founders and a 120-minute organization delay initiate a GC. This is not a calibrated human response.
Not implemented: class switching, sequence-level SHM, CD8/cross-presentation, Treg/Tfr regulation, calibrated cytokine diffusion, HEV recruitment, egress, live-vaccine replication or whole-node anatomy. All B-cell outputs remain IgM.
Jev: server-side API key, individual local observations, validated action menus, recorded probability distributions and a hard request cap. This public recording contains actual Jev choices. A proposed competing-fate rule was introduced at 60 hours and is disclosed in the recording. Playback makes no API calls.